Myeloid Sarcoma of the Bladder in a Patient with Chronic myelomonocytic Leukaemia A Case report and Literature Review

Main Article Content

Rebecca Smith
Bashir Mohamed
Jeremy Nettleton

Abstract

Background
Myeloid sarcoma is a rare extramedullary tumour of immature granulocytes, most commonly involving the skin, bone, lymph nodes, and soft tissue. It is usually associated with a diagnosis of relapsed or de novo acute myeloid leukaemia, acute lymphoblastic transformation of a myelodysplastic/myeloproliferative neoplasm, or can occur as isolated myeloid sarcoma.
Case report
A 66-year-old female with a 7-year history of stable chronic myelomonocytic leukaemia presents with urgency, frequency, dysuria symptoms, and without new constitutional symptoms. She is found to have atypical, multifocal lesions on the right posterolateral wall of the bladder with associated hydronephrosis. Pathology reveals the diagnosis as myeloid sarcoma; surprisingly, bone marrow evaluation does not show evidence of acute leukaemic transformation.
Conclusions
Myeloid sarcoma occurring in patients with chronic myelomonocytic leukaemia is extremely rare, and there are no cases reported in the English literature of these patients developing lesions in the bladder. The urological manifestations of an underlying haematological malignancy are best managed with a combination of systemic chemotherapy and allogeneic stem cell transplant, and in this case, the only surgical intervention required was ureteric stenting and tissue biopsy. Although rare, it is essential to consider alternative diagnoses when confronted with an atypical bladder tumour; failure to do so may result in patient harm by exposure to unnecessary intervention and delay to potentially curative treatment.

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How to Cite
Smith, R., Mohamed, B., & Nettleton, J. (2022). Myeloid Sarcoma of the Bladder in a Patient with Chronic myelomonocytic Leukaemia: A Case report and Literature Review. Journal of Endoluminal Endourology, 4(3), e36-e43. https://doi.org/10.22374/jeleu.v4i3.132
Section
Case Reports
Author Biographies

Rebecca Smith, Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

Bashir Mohamed, Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

Jeremy Nettleton, Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

Cheltenham General Hospital, Gloucestershire Hospitals NHS Foundation Trust, UK

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